Stem cells are maintained in a pluripotent state that enables them to serve as source for the formation of new cells, tissues and organs. Recent findings suggest that pluripotency depends on the epigenetic state of the stem cells, but the mechanisms controlling this state and the transition into committed cell fates remain to be revealed.
We are seeking highly motivated candidates to investigate the epigenetic mechanisms regulating pluripotency in the stem cell niche of the Arabidopsis root meristem. Our previous work identified WOX5 as an epigenetic key regulator of root stem cells and developed tools to dissect cell fates at the single-cell level (Pi et al, Developmental Cell 33, 576-88 and unpublished).
In addition to standard genetic and molecular expertise, the successful applicant will have a good background in chromatin studies such as Cut&Run and ChIP and in the bioinformatic analysis of genomic data. Transcriptome, chromatin, and live imaging data will be combined to create models of the epigenetic code underlying pluripotency. Together with single-cell analysis, induced pluripotent stem cells (iPS) technology will be used. Results will be used to develop breeding concepts based on stem cell biology with our international collaborators.
Full time position for three years with the possibility of extension.
The position is open immediately until a suitable candidate has been found.
Competitive salary and social benefits.
Participation in cutting-edge research projects.
Various training opportunities.
Professional career development & soft skills.
Lab and university environment
We are an international research group with postdoctoral and Ph.D. fellows from several different countries. The lab language is English. For further information on our research, publications and group, please visit our homepage (www.biologie.uni-freiburg.de/LauxLa
Participation in cutting-edge research projects as part of the German Excellence Program.
We are an international research group with postdoctoral and Ph.D. fellows from several different countries. The lab language is English. German is not required. For further information on our research, publications and group, please visit our homepage (www.biologie.uni-freiburg.de/LauxLab).
How to apply
To apply, please send your CV including your research experiences and your future interests to Thomas Laux (email@example.com).
The University of Freiburg with a strong and international scientific community is routinely among the best German universities in international rankings. Advanced facilities for systems biology, protein analysis, and imaging are available. The city of Freiburg is located in the Black Forest region, next to France, Switzerland, and the Alps and is appreciated for its mild climate.
Experiences in studying DNA-Protein interaction at the genomic level, such as ChIP and Cut &Run and bioinformatic analysis of genomic data.