Q-State is the only company now offering comprehensive genomic services ranging from genetic sequencing to mutation modelling and screening to targeted antisense oligonucleotide (ASO) design, with application to individuals as well as populations. Underlying these services is the company’s expertise in functional genomics, stem cell biology, gene editing, and machine-learning based bioinformatics. Q-State’s proprietary OptopatchTM technology, in particular, enables the company to gain unparalleled physiological insights into personalized models of genetic nervous system conditions. Q-State also offers screening services in these models with its in-house new chemical entity (NCE) and repurposing libraries, and with custom-constructed ASOs. These collective services are available to individuals through their physician and to larger underserved populations through drug development partnerships with pharmaceutical companies. Q-State’s approach enables rapid drug discovery opportunities with shorter timelines and powers new treatment paradigms for genetic disease.
We are seeking a self-motivated Senior Scientist to develop novel all-optical electrophysiology assays and to help enable Q-State to develop therapies for diseases of the central nervous system. In particular, we are seeking a candidate to build novel optogenetic assays for probing differential pharmacology on excitation-inhibition in both rodent and human cell culture as well as rodent brain slice. The developed assays, both excitability and synaptic-based, will be used for neuronal disease phenotyping and drug screening applications. The ideal candidate will be comfortable and experienced with the biological, genetics and instrumentation dimensions of such assays. The Senior Scientist will help to conduct validation studies of developed assays, and monitor quality control and performance metrics as the assay is transferred to production operations. Throughout development, the Sr. Scientist will demonstrate effective collaboration on experimental design, rigorous data analysis, and clear communications. The Senior Scientist candidate will also be expected to carefully manage timelines and budgets for relevant projects.
Nice to haves
Q-State is a well-funded startup company with 60+ employees located in Cambridge, MA. We offer a comprehensive benefits package and competitive compensation.
Find out more: Visit the company website (complete with beautiful pictures of neurons): http://www.qstatebio.com
Watch Q-State cofounder Adam Cohen’s TEDx Talk at http://goo.gl/Gj28pr
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