Post-doctoral researchers are invited to join a dynamic team investigating the role of microglial cells in neuroinflammation at the University of Pennsylvania. The first position focuses on enhancing autophagy and clearance of waste by microglial and epithelial cells by modulating lysosomal function. The second position probes the role of the P2X7 receptor and the NLRP3 inflammasome on microglial cells in cytokine release, neuroinflammation and neuronal death. Both positions will use mechanistic understanding to develop novel treatments to prevent neuroinflammation and evaluate their ability to preserve neural function. Treatment strategies include small molecules, FDA-approved drugs, nanoparticles and gene therapy. Successful candidates are encouraged to work together with the PI to advance the research project. Responsibilities include experimental design, data analysis, manuscript writing, collection and preparation of samples, live-cell imaging experiments, molecular analysis and measurements of efficacy. Researchers are encouraged to present at national and international scientific conferences and helped to apply for funding.
Candidates should expect to receive their PhD within 3-6 months or have obtained one within the last 2 years in the fields of molecular biology, cell biology, neuroscience, or a related biomedical science field. A strong background in molecular biology and mouse model design is required, with experience using gene therapy, CRISPR approaches, neuro-glial interactions, live-cell imaging, patch clamping, drug development and/or nanoparticles an advantage. The successful candidate will possesses the ability to work both independently as well as in a collaborative environment and should have documented success in research including publications in international journals on relevant topics.