Over the next 3 years, the University of Pittsburgh, which currently ranks 4th in NIH funding to universities and research institutions, plans to hire 10-12 highly creative faculty investigators to join a multidisciplinary team focused on determining the molecular root cause(s) of Alzheimer’s disease (AD) and pursuing strategies to prevent and/or treat it.
With substantial financial support, we are creating a new state-of-the-art basic research center dedicated to bringing together – physically and intellectually – a critical mass of basic and translational AD investigators. We welcome investigators who approach AD from diverse perspectives, including neurobiology, genetics, molecular and cell biology, structural biology, mitochondrial biology, neuroinflammation, immunology/virology, microbiome/metagenomics, computational biology, and other fields.
We have established a marmoset colony on-site that will support translational studies in genetically engineered AD models using customized 9.4T MRI, PET-CT, and two-photon microscopy, all capable of imaging awake, behaving animals. We also support components of several NIA translational initiatives, including the mouse MODEL-AD program and AD Centers for Discovery of New Medicines. Team members will also have access to patient data, biospecimens, expertise, and resources from our Alzheimer’s Disease Research Center (ADRC), brain bank, and the PET Research Center, where Pittsburgh Compound B was discovered and developed.
Additional resources include equipment and expertise in the Departments of Structural Biology (including tomographic cryo-electron microscopy), Center for Biologic Imaging, and Magnetic Resonance Research Center and comprehensive research sequencing at the UPMC Clinical Genome Center.
Team members will have the opportunity to mentor outstanding graduate students from multiple programs, including the Medical Scientist Training Program (MD-PhD), Physician Scientist Training Program (MD-MS), joint graduate programs in Computational Biology and Neural Cognition/Computation with Carnegie Mellon University (CMU), Bioengineering, Biomedical Informatics, Clinical and Translational Science, Computational Modeling and Simulation, Integrative Systems Biology, Interdisciplinary Biomedical Program, Microbiology and Immunology, Molecular Biophysics and Structural Biology, and Neuroscience.
Assault members will be encouraged to collaborate with faculty from the University of Pittsburgh’s Brain, Neurodegenerative Diseases, Aging, Precision Medicine, Drug Discovery, and Clinical and Translational Science Institutes and numerous schools across Pitt as well as other universities in the Pittsburgh area, including CMU, whose faculty also participate in the Assault on Alzheimer’s. In addition, our newest School of Computing and Information is committed to supporting an AD initiative that integrates novel tools in artificial intelligence, text mining, machine learning, and causal discovery, and the Pittsburgh Supercomputing Center is available to support big-data analyses.
We seek candidates at tenure-stream Assistant and Associate Professor levels with an MD and/or PhD or equivalent degree who have demonstrated exceptional qualifications in research, novel hypotheses and approaches to AD research, and excellent collaboration and communication skills.
We offer competitive start-up packages, opportunities for intramural pilot funding, and one of the most livable and innovative cities in the US. To be considered, please send a brief cover letter, CV, 1-page statement of AD research interests, PDFs of 2-3 recent publications, and contact information for 3 references to ADrecruit@pitt.edu.
The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EEO/AA/M/F/Vets/Disabled