Pfizer is making significant investment in the creation of novel, first-in-class therapeutics, by combining internal discovery and validation of drug targets with external partnerships to produce clinical drug candidates for the Pfizer pipeline. This position is within the Target Sciences (TS) group, which has expertise in human genetics, functional genomics, computational biology and data management, and target validation biology. TS works together with Pfizer’s nationwide Centers for Therapeutic Innovation (CTI) within the broader External Science & Innovation division of World R&D to deliver novel, innovative pipeline candidates based on emerging science. A particular area of emphasis is the proactive seeding of new multi-investigator academic collaborations, centered on areas of emerging science including oncology and immunology and designed to deliver new target hypotheses for Pfizer’s next generations of therapeutics.
The primary responsibility for this position is to generate and validate new target hypotheses for drug discovery based on human biology, by integrating population genetics, rare variant and familial genetics, protein and message expression in human tissue, and contextual literature information. Sources are public data, commissioned data, internal clinical data, and existing networks of academic partnerships focused on disease mechanisms of highest priority. An additional responsibility is the hands-on application of genetics and computational methods, together with TS colleagues, to evaluate new and prioritize existing drug discovery programs in CTI. Finally, the successful applicant will cooperate with TS colleagues to enable the next generation of genotype-phenotype population genetic resources critical to support emerging science hypotheses. The position requires deep expertise in human genetics and computational methods, understanding of molecular mechanisms of disease, and the ability to represent Pfizer externally and TS internally to translate emerging science into targets ready to enter the pipeline.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
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