The laboratory of Lauren Aleksunes, PharmD, PhD, DABT is seeking postdoctoral fellows to work on mechanistic and translational research projects funded by NIH that investigate xenobiotic transporter biology and toxicology. Based at Rutgers University in New Jersey, the Aleksunes team has access to outstanding core facilities, dynamic researchers and trainees and excellent opportunities for career development. State-of-the-art Core Facilities are available for Genomics, Genetics, Proteomics, Imaging, Histopathology, Analytical Chemistry, Flow Cytometry and Cell Sorting, High Content Imaging, Gene Editing, and Biostatistics. Postdocs are members of the Rutgers Association of Toxicology Students (RATS), a professional and social network of trainees that fosters peer support and inter-laboratory collaboration.
Project 1 (NIH R01ES029275) - Placental Responses to Environmental Chemicals
• This project aims to identify transporters that regulate the maternal-fetal disposition of environmental chemicals using in vivo transporter knockout models, placenta-on-a-chip microfluidics system, and a birth cohort of mother-baby pairs. Research techniques include qPCR, transport assays, IHC, ICP/MS, placental explant cultures, biomarkers, and proteomics.
Project 2 (NIH R01GM123330) - Drug Disposition and Nephrotoxicity
• This project aims to evaluate renal transporter-mediated drug-drug interactions using in vitro transporter assays, LC/MS and ICP/MS, and nephrotoxicity biomarker analysis in specimens from oncology patients.
Project 3 (NIH R01ES021800) - Gene-Environment Interactions in Neurodegeneration
• This project aims to study the effect of transporter genetic polymorphisms on the penetration of chemicals into the brain and degree of neurotoxicity. Mechanisms of neurodegeneration and neuroinflammation are evaluated using knockout mice, blood-brain barrier and microglial cultures, stereology, transporter assays, and LC/MS.
Rutgers University is located in central NJ with convenient access to NYC and Philadelphia as well as beautiful beaches, lakes, and mountains for recreation. More information about the Aleksunes lab is available at our website.
Candidates should have a Ph.D. degree in pharmacology/toxicology or a related biomedical science including pharmaceutical sciences, biochemistry, biology, molecular biology, physiology, etc. Fellows should be highly motivated and hard-working scientists capable of effectively working on independent and team projects. Excellent oral and written communication skills are required.
To apply, please email your curriculum vitae, cover letter describing research experiences and future goals, and list of 3 references to Dr. Aleksunes at firstname.lastname@example.org.