The laboratory of Matthew Poy at the new Institute for Fundamental Biomedical Research at Johns Hopkins All Children's Hospital in St. Petersburg, Florida is seeking two post-doctoral fellows for a project on the characterization of the microRNA pathway in the regulatory role of the CNS in energy homeostasis.
The metabolic syndrome is characterized by obesity, hyperglycemia, and insulin resistance and alterations to both insulin and leptin signaling cascades can contribute to a pathogenic state. Previous studies by our group have shown that microRNAs are highly regulated in the pancreatic islets of insulin-resistant mouse models and in the islets of type 2 diabetic human subjects and play a key role in the growth and function of the pancreatic beta cell (Tattikota et al. Cell Metabolism, 2014). Many of the genes targeted by microRNAs in the endocrine pancreas are abundantly expressed in the CNS, suggesting these factors serve in a similar capacity across multiple tissues. In addition, the susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis and we recently characterized the role of CADM1 and CADM2 in the regulation of body weight (Rathjen et al. Nature Neuroscience, 2017; Yan et al. Molecular Metabolism, 2018). Cadm1 is targeted by several miRNAs in the CNS and future aims are directed towards understanding the role of the microRNA pathway in the CNS in managing systemic energy metabolism and metabolic stress responses as well as elucidating its specific mechanisms of action. The precise research aims are flexible and each project will be tailored to the strengths of the individual.
Applicants must have an M.D. or Ph.D. in a relevant subject (i.e. Molecular Biology, Biochemistry, Physiology, or Genetics) and a publication history. Excellent organizational and record-keeping skills, a meticulous approach to practical work, the ability to work effectively and flexibly as part of a team, and ability to plan and execute experimental research independently are required. Applicants should provide a CV, a cover letter describing career goals, and contact information for at least two referees.
Interested individuals can forward materials to: