Postdoctoral opportunities are available to study the molecular basis and neural circuitry of sleep regulation in the lab of William Joiner at the University of California San Diego.
Sleep is essential for human health and well-being. As a result, insufficient sleep is thought to contribute to many disorders. However, the underlying mechanisms and even the needs that sleep fulfills remain among the great mysteries facing neuroscience. Using Drosophila melanogaster, which shares fundamental mechanisms of sleep regulation with mammals, we have developed a novel high- throughput assay to measure sleep need. Using this assay in unique anatomical, genetic, and proteomic screens we have identified both neural circuit components and molecules that contribute to fulfillment of sleep need, and we have implicated some of these in memory formation. We have also identified processes that may co- opt sleep need during pathophysiological conditions. Postdoctoral fellows thus have a range of interesting projects to work on that are relevant to fundamental neuroscience and disease pathology. These projects offer opportunities to develop skills in behavioral genetics, molecular biology, biochemistry, cell biology, optical imaging and electrophysiology. The Joiner lab also studies regulation of mammalian neurotransmitter receptors by a family of evolutionarily conserved endogenous prototoxins.
The University of California San Diego (UCSD)
Graduate science programs at UCSD are consistently ranked at the top of national polls, including programs in Neurosciences, Biomedical Sciences, Biological Sciences, Bioengineering, Chemistry & Biochemistry, and Oceanography. The vibrant local sleep and circadian research community is connected through the Center for Circadian Biology, which includes dozens of labs at UCSD, the Salk Institute, and The Scripps Research Institute. UCSD itself is located in beautiful La Jolla, within walking distance of the Pacific Ocean, beaches and hiking trails, and within a short drive of downtown San Diego and its rich cultural opportunities.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, race, color, religion, sex, national origin, disability, age or protected veteran status.
Experience in neuroscience and genetics is advantageous for this position, but other applicants with a strong record of research productivity will be considered as well. Applicants should have a Ph.D. or be nearing the completion of their Ph.D.