This posting is to fill open positions in our T32 post-doctoral training grant, "The Pathophysiology of Occlusive Vascular Disease," which includes cerebrovascular disease, in the laboratory of Mark S. Shapiro, Ph.D. in the Department of Molecular and Integrative Physiology. We study the physiology, regulation and functional role of a variety of ion channels in neurons and other excitable cells, using a range of cutting-edge molecular, cellular and integrative approaches. This T32 training grant that Dr. Shapiro participates in, has produced a number of NRSA F32-funded investigators who have gone on to successful faculty positions. The positions should be filled by the end of August 2017.
In my group, previous and current post-docs supported by this T32 training grant have studied, or are studying, the roles of KCNQ potassium ion channel activity in neurons of the brain as a neuroprotective mechanism against brain damage induced by stroke, traumatic brain injury (TBI), and epileptic seizures leading to epileptogenesis. The project on TBI and epileptogenesis is also supported by a grant from the DoD CDMRP program. We use whole-animal in vivo stroke, TBI and epilepsy models in a variety of wild-type or genetically-altered mice, and study the brain using brain-slice electrophysiology, immunochemistry, in vivo confocal imaging and in vivo behavioral assays. We are very physiological and quantitative in approach, yet with strong translational relevance and potential. The candidate can thus learn patch-clamp methods and innovative imaging (deep brain to single-cell) techniques, in conjunction with molecular and live-animal behavioral approaches. T32-supported candidates benefit from a number of grant-writing and career-building workshops given by the Office of Postdoctoral Affairs and the Office of Career Development, which have proven extremely valuable as post-doctoral fellows progress to independence. We also employ super-resolution microscopy, molecular biology, biochemistry, patch clamp of tissue-culture cells, dissociated neurons and neurons in brain slice, to discover the intracellular 2nd-messengers the couple receptors to alterations in ion channel activity and cellular function and to probe their role in prevention of brain damage in cerebrovascular disease.
To apply, please email Dr. Shapiro at firstname.lastname@example.org. UTHSCSA is a leading academic research university, and the Department of Cell and Integrative Physiology in the School of Medicine contains a vibrant mix of neuroscientists, cellular/molecular physiologists and integrative systems scientists who interact often and well. The Shapiro lab at UTHSCSA contains an interdepartmental and collaborative group of funded and productive neuroscientists and cardiovascular researchers. Please bear in mind, that upon interviewing, if we both decide that you might be a better fit in one of our many T32 mentors, this can be arranged. San Antonio is a vibrant and multi-cultural city with many attractions, and offers a very affordable cost of living for a post-doctoral fellow supported by this T32 training grant.
We seek highly-motivated and hard-working candidates with strong scholarly outlook, and a keen desire to perform cutting-edge biomedical research. A background in neurophysiology or cardiovascular physiology at the cellular levels, mammalian models and ion channel physiology/pharmacology is preferred, but all candidates will be considered. Since this is a T32-supported or DoD-supported position, US citizenship or permanent residency status (green card) is required, but non-citizens or permanent residents can apply to the sister ad which does not have that requirement.
All postdoctoral appointments are designated as security sensitive positions.
The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer, including protected veterans and persons with disabilities.
Candidates must have a Ph.D. or M.D. in a relevant discipline and be American citizens or have permanent residence ("green card"). Some experience in a highly relevant discipline in cellular or molecular Neuroscience or Cardiovascular research is highly preferred.