Our research on human subjects involves investigation of diffusion, including anomalous diffusion, in the assessment of muscle quality and age-related muscle loss (sarcopenia). Additional studies center on brain myelin studies using novel Bayesian reconstruction algorithms and filtering methodologies. A recent initiative is the development of in vivo one- and two-dimensional relaxometry studies of muscle and brain. Muscle bioenergetic studies using the 31P nucleus are also of central importance, and make use of the extensive database of the Baltimore Longitudinal Study on Aging. Results are correlated with a wide range of biological and functional outcomes to explore the effects of biochemical and structural tissue changes that occur with age and age-associated disease. All human subjects work is performed using our research-dedicated 3T whole-body 32-channel Philips Achieva MRI system, capable of both proton and heteronuclear spectroscopy.
Preclinical work centers on imaging and relaxometry studies of cartilage, including development and application of approaches from the areas of inverse problems and compressed sensing. Our research currently emphasizes multiexponential and multidimensional relaxometry, and other advanced signal acquisition and processing techniques. A recent initiative involves model selection in signal analysis for tissue characterization. For preclinical work, MRI instrumentation consists of a vertical wide-bore 9.4T Bruker Avance III system with microimaging and solids capability and a Bruker 7T/30 cm Biospec Avance system.
Specific research activities within the above areas will depend upon the interests and background of the successful candidate.