Integrative Neuroscience and Neural Circuitry of Sleep/Wake
The Center for Neurosciences at SRI International has an opening for a Postdoctoral Fellow or Research Scientist with a background in integrative neuroscience and expertise in neural circuit studies using electrophysiological, optogenetic, pharmacogenetic and/or neuroanatomical approaches. The researcher will work with a team of Research Scientists, Postdoctoral Fellows and technical staff to investigate the properties of neuronal cell types involved in sleep/wake regulation, their interconnections, and their roles in the circuits underlying arousal state control. Cortical nNOS/NK1 neurons (Morairty et al., 2013, PNAS 110:20,272; Dittrich et al., 2014, Neuropsychopharmacology 40:632), hypothalamic hypocretin/orexin (Tabuchi et al., 2014, J. Neurosci. 34:6495; Black et al., 2014, J. Neurosci. 34:6485; Parks et al., 2015; Neuropsychopharmacology) and MCH neurons (Tsunematsu et al., 2014, J. Neurosci. 34:6896) are of particular interest.
In vivo recording of brain activity using electrophysiological and optical techniques
Optogenetic, pharmacogenetic and other approaches for precise manipulation of neuronal activity
Design, execute, and analyze experiments that investigate the function of individual cells or cell types in micro and macro circuits
Work with others to develop a pipeline for large-scale, systematic characterization of the physiological and connectional properties of different neuronal cell types
Work with others to develop paradigms to correlate physiological, morphological and molecular properties within a single neuron
Seek and evaluate new cutting-edge technologies in related areas
Publish/present findings in peer-reviewed journals/scientific conferences
Present regular summary of progress to other researchers in the laboratory and larger organization
D. or M.D. in a biological life science or related discipline with zero to seven years’ post PhD experience
Working experience in physiological neuroscience research
Experience and technical knowledge in brain slice electrophysiology and synaptic physiology
Experience with use of viral vectors and stereotaxic surgery
Experience with microendioscopy/optical recording of brain activity in vivo a plus
Strong publication record
Ability to meet aggressive timelines and deliverables; strong commitment to collaborative teamwork
Excellent problem solving and experiment managing skills
Strong written and verbal communication skills
Strong computer programming and data analysis skills preferred
This position will require a post offer, pre-laboratory placement physical examination. Employment at SRI is contingent on successful completion of a background check.
SRI Biosciences, a division of SRI International, integrates basic biomedical research with drug and diagnostics discovery and preclinical and clinical development. SRI International, a research center headquartered in Menlo Park, California, creates world-changing solutions to make people safer, healthier, and more productive.
SRI International is committed to hiring and retaining a diverse workforce. We are proud to be an Equal Opportunity/Affirmative Action Employer, making decisions without regard to race, color, religion, creed, sex, sexual orientation, gender identity, marital status, national origin, age, veteran status, disability, or any other protected class.
SRI International is a nonprofit, independent research and innovation center serving government and industry. We provide basic and applied research, laboratory and advisory services, technology development and licenses, deployable systems, products, and venture opportunities.Our research and innovations have led to new industries and products that impact people’s lives every day—from the computer ...mouse and interactive computing to medical ultrasound, cancer drugs, and much more.SRI bridges the critical gap between research universities or national laboratories and industry. We move R&D from the laboratory to the marketplace to create high value and real innovation. And the platforms we build today are designed to meet tomorrow’s needs. For example, an artificial intelligence project for DARPA led to the development of Siri for Apple’s iPhone.SRI works on some of the world’s most important problems, collaborating across technical disciplines to spark new ideas and solutions. We believe in open innovation, bringing the best talent to the challenge at hand.