The Providence Airway Centre (PAC) resides in the Centre for Heart Lung Innovation (HLI) at St. Paul’s Hospital (SPH), a busy tertiary care facility in Vancouver, and a teaching hospital of The University of British Columbia (UBC). Established in 1976 by Drs. Peter Paré and James Hogg, HLI is the leading centre for chronic obstructive pulmonary disease (COPD) research in Canada. The vision of PAC is to bring new therapeutic and biomarker solutions to patients with COPD and asthma and enable precision health, in order to address the growing burden of these airway conditions in BC and elsewhere. To achieve this vital goal, PAC is focused on translating “bench” findings to new therapeutic and biomarker targets, which can ultimately transform patient care for those with chronic airway disease.
We are seeking an outstanding scientist or post-doctoral fellow to help drive our research efforts in discovering and validating important therapeutic targets in chronic airway diseases. This highly motivated and creative individual will work closely with a diverse team of clinicians, professors, students, managers, biologists, geneticists, bioinformaticians, biomedical engineers and industry partners to create/implement a robust target identification and validation pipeline to advance our target discovery projects. Our intent is to identify a scientist with the potential to become a thought leader at PAC, actively and independently evaluating and driving new avenues of research. Expertise in COPD and asthma is highly preferred.
KEY DUTIES AND RESPONSIBILITIES
• Implement approaches to analyze and characterize effects of genetic manipulation across various cellular models • Design and execute in vitro experiments to assess and develop novel assays, techniques and technologies to support current and future target identification and validation programs • Identify and determine appropriate ranges of critical assay process parameters to ensure robust, repeatable and accurate results • Participate in and contribute to cross-functional teams to support target identification and validation, including assay development • Author, review and approve SOPs, study protocols, reports and other scientific and quality documents • Present scientific data to colleagues in weekly group meetings, prepare and present internal and external communications (e.g., presentations, posters, and publications), as well as author and submit articles to peer-reviewed journals as required • Supervision of research technicians and graduate students • Establish and manage external collaborations • Work independently, collaboratively, and lead multidisciplinary teams • Perform additional duties to support the safe and efficient operation of the laboratory, and other duties as assigned
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities • Able to develop and maintain effective cross-functional working relationships and partnerships • Good interpersonal, verbal and written communication skills • Self-motivated and willing to accept temporary responsibilities outside of initial job description • Ability to respond positively and constructively to requests for support from across the organization
• Ph.D. in Life Sciences with a focus on cell and molecular biology or related field • Strong understanding of assay development, phenotypic screening and gene editing technologies (e.g., CRISPR) • Postdoctoral training and/or experience establishing and validating cell-based assays and quantifying pharmacological effects in these assays • Working knowledge of cell tissue culture techniques including both cell lines and preparation and maintenance of primary cell cultures • Enthusiasm for laboratory work, and good problem solving skills • Excellent oral and written communication skills and initiative • Excellent record keeping, attention to detail • Demonstrated leadership and supervisory skills • Ability to work both independently and in a team environment and be flexible in adapting to change • Demonstrated hands-on experience in the development of target identification and validation approaches preferred
How to Apply
Interested candidates should forward their resume and/or Curriculum Vitae, including references and a cover letter, to the attention of PAC Program Manager Tony.Yang@hli.ubc.ca
Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.
All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.