We seek a talented and motivated postdoc in Neuroscience to join Sila Ultanir’s laboratory studying kinases and brain development.
A postdoctoral research position is now open in the laboratory of Sila Ultanir. We are seeking a motivated scientist interested in kinase signalling pathways in neuronal development. Candidate will join an exciting research project to uncover molecular mechanisms of a rare neurodevelopmental disorder – the CDKL5 deficiency syndrome. Loss of function mutations of the X-linked CDKL5 gene cause severe learning and sensory-motor defects and difficult-to-control seizures in children. CDKL5 is a serine/threonine kinase highly enriched in mammalian brain; its molecular and cellular function is not well-understood. Knowledge of CDKL5’s substrates can shed light on kinase’s molecular and cellular mechanisms and help formulate therapeutic approaches to alleviate disease symptoms. The proposed project will address function of novel unpublished substrates of CDKL5 discovered in our lab using transgenic mice and human induced pluripotent stem cell (hIPSC) models. We are particularly interested in how CDKL5 regulates dendritic development and synaptic function. Successful candidate will use various techniques including electrophysiology, biochemistry, cellular, molecular biology techniques and live imaging. Candidate will have the opportunity to interact with London’s strong neuroscience community. Project is partially funded by CDKL5 Charity LouLou foundation. Human IPSC experiments will be conducted in collaboration with Alysson Muotri’s laboratory at UCSD.
Our lab studies multiple kinases which play roles in neuronal development and nervous system disorders. We use chemical genetic, mass spectrometry and biochemistry methods to determine and validate novel kinase substrates (Ultanir et al. Neuron 2012, Ultanir et al. Neuron 2014). We analyse neuronal dendrite and synapse development in kinase knockout mouse models and CRISPR generated phosphomutant mice using electrophysiology in acute slices and imaging of synaptic structures, such as spines and synaptic proteins in neural cultures. We also investigate how membrane trafficking and microtubule based transport in neuronal dendrites are regulated by kinases using live imaging. For more information about the lab please visit https://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/sila-konur-ultanir/
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:
Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.